Former Buffalo Bills (and current San Francisco 49ers) defender Leonard Floyd will be facing off against his old club this ...

The Bills are off to their best start since 1993, and could punch their ticket to the 2024 playoffs as early as this week.

The Buffalo Bills have opened the 21-day practice windows of offensive tackle Tylan Grable and defensive tackle DeWayne ...

Buffalo Bills coach Sean McDermott looked and sounded refreshed as he and his team returned from its bye week.

Three teams face playoff-clinching scenarios in Week 13. Here's what the Bills, Lions and Chiefs need to earn a playoff berth ...

Wray Carlton, 87, is about six weeks into his recovery. He and his wife, Susan, recently sat down with The Buffalo News to ...

The highly anticipated Buffalo Bills clash against the San Francisco 49ers, scheduled for Sunday at Highmark Stadium, faces ...

San Francisco 49ers defensive end Nick Bosa missed Wednesday's practice as the team began preparations for Sunday's game ...

Before the season began, this week's game between the San Francisco 49ers and Buffalo Bills looked daunting. The 49ers were ...

LB Fred Warner, WR Deebo Samuel Sr., RB Christian McCaffrey and DL Nick Bosa identified key areas for improvement as the team ...

Bills' QB Josh Allen is the current favorite for MVP. Expectations aren't something I like to make a habit. However, it's ...

The Buffalo Bills will host the San Francisco 49ers in a somewhat hostile environment. Sean McDermott knows how to handle ...